Mechanisms that explain the hygiene hypothesis for allergy and asthma are unclear. A mouse model that cohouses ‘dirty’ pet-store mice with clean laboratory mice might help to understand this immunology.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Strachan, D. P. Br. Med. J. 299, 1259–1260 (1989).
Shanahan, F. Clin. Exp. Immunol. 160, 92–97 (2010).
Sekirov, I., Russell, S. L., Antunes, L. C. & Finlay, B. B. Physiol. Rev. 90, 859–904 (2010).
Block, K. et al. Nat. Immunol. https://doi.org/10.1038/s41590-022-01350-8 (2022).
Beura, L. K. et al. Nature 532, 512–616 (2016).
Huggins, M. A. et al. Cell Rep. 28, 1729–1743 e5 (2019).
Von Ehrenstein, O. S. et al. Clin. Exp. Allergy 30, 187–193 (2000).
Kummeling, I. et al. Pediatrics 119, e225–e231 (2007).
Kero, J. et al. Pediatr. Res. 52, 6–11 (2002).
Feehley, T. et al. Nat. Med. 25, 448–453 (2019).
Abdel-Gadir, A. et al. Nat. Med. 25, 1164–1174 (2019).
Fujimura, K. E. et al. Proc. Natl Acad. Sci. 111, 805–810 (2014).
Atarashi, K. et al. Science 331, 337–341 (2011).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Umetsu, D.T. Understanding microorganisms in the prevention of allergy. Nat Immunol 23, 1657–1658 (2022). https://doi.org/10.1038/s41590-022-01356-2
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41590-022-01356-2
