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Mouse long-lived plasma cells develop from multiple origins

By combining single-cell mRNA sequencing and a genetic pulse–chase mouse model, we identified multiple subsets of mouse long-lived plasma cells and showed that these cells can originate from diverse developmental routes.

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Fig. 1: Mouse PC heterogeneity and long-lived subsets.


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This is a summary of: Liu, X. et al. Heterogeneous plasma cells and long-lived subsets in response to immunization, autoantigen and microbiota. Nat. Immunol. (2022).

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Mouse long-lived plasma cells develop from multiple origins. Nat Immunol 23, 1521–1522 (2022).

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