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Mouse long-lived plasma cells develop from multiple origins

By combining single-cell mRNA sequencing and a genetic pulse–chase mouse model, we identified multiple subsets of mouse long-lived plasma cells and showed that these cells can originate from diverse developmental routes.

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Fig. 1: Mouse PC heterogeneity and long-lived subsets.


  1. Slifka, M. K., Antia, R., Whitmire, J. K. & Ahmed, R. Humoral immunity due to long-lived plasma cells. Immunity 8, 363–372 (1998). This study showed that PCs can persist without replenishment by memory B cells.

    Article  CAS  PubMed  Google Scholar 

  2. Amanna, I. J., Carlson, N. E. & Slifka, M. K. Duration of humoral immunity to common viral and vaccine antigens. N. Engl. J. Med. 357, 1903–1915 (2007). This study measured the abundance of LLPCs within human BM and demostrated the heterogeneity of the BM PC compartment.

    Article  CAS  PubMed  Google Scholar 

  3. Halliley, J. L. et al. Long-lived plasma cells are contained within the CD19CD38hiCD138+ subset in human bone marrow. Immunity 43, 132–145 (2015). This longitudinal study analyzed the half-lives of human serum antibodies to common viral antigens, showing that they span a rather wide range and do not correlate with the number of memory B cells in the circulation.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Robinson, M. J., Webster, R. H. & Tarlinton, D. M. How intrinsic and extrinsic regulators of plasma cell survival might intersect for durable humoral immunity. Immunol Rev 296, 87–103 (2020). This comprehensive review summarizes known requirements for LLPC differentiation.

    Article  CAS  PubMed  Google Scholar 

  5. Bunker, J. J. et al. Natural polyreactive IgA antibodies coat the intestinal microbiota. Science 358, eaan6619 (2017). This study profiled the antigen specificities of a large collection of mouse IgA-producing PCs, and showed that many of them are innate-like and microbiota reactive.

    Article  PubMed  PubMed Central  Google Scholar 

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This is a summary of: Liu, X. et al. Heterogeneous plasma cells and long-lived subsets in response to immunization, autoantigen and microbiota. Nat. Immunol. (2022).

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Mouse long-lived plasma cells develop from multiple origins. Nat Immunol 23, 1521–1522 (2022).

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