We identified the transmembrane protein CMTM4 as an essential component of the IL-17 receptor. CMTM4 is required for membrane expression of IL-17 receptor subunit C and activation of IL-17A pro-inflammatory signaling. Lack of CMTM4 largely protects mice from experimental psoriasis, which suggests that targeting CMTM4 might alleviate IL-17-mediated autoimmunity.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Li, X. et al. IL-17 receptor-based signaling and implications for disease. Nat. Immunol. 20, 1594–1602 (2019). A review article summarizing the role of IL-17 receptor signaling in the regulation of the immune system.
Draberova, H. et al. Systematic analysis of the IL-17 receptor signalosome reveals a robust regulatory feedback loop. EMBO J 39, e104202 (2020). In this paper, we developed the methodology for mass spectrometry analysis of the IL-17 receptor signaling complex.
Mezzadra, R. et al. Identification of CMTM6 and CMTM4 as PD-L1 protein regulators. Nature 549, 106–110 (2017). This paper shows that CMTM6, and to lesser extent CMTM4, regulates the expression of the immunoregulatory protein PD-L1.
Carroll, M. C. The complement system in regulation of adaptive immunity. Nat. Immunol. 5, 981–986 (2004). A review article describing the role of tetraspanin CD81 in B cell complement receptor.
Burr, M. L. et al. CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity. Nature 549, 101–105 (2017). This paper shows the major role of CMTM6 in the regulation of PD-L1.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Knizkova, D. et al. CMTM4 is a subunit of the IL-17 receptor and mediates autoimmune pathology. Nat. Immunol. https://doi.org/10.1038/s41590-022-01325-9 (2022).
Rights and permissions
About this article
Cite this article
CMTM4 is required for IL-17A signaling. Nat Immunol 23, 1525–1526 (2022). https://doi.org/10.1038/s41590-022-01344-6
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41590-022-01344-6
