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T cell development

Fine-tuning Notch1 by the stage-specific enhancer

DNSe, a double-negative thymocyte-specific Notch1 enhancer, is essential for activation of Notch1 expression and has a central role in T-cell-lineage commitment during the earliest stages of thymocyte development.

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Fig. 1: A stage-specific enhancer activates Notch1 transcription and promotes DN thymocyte differentiation.

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Correspondence to Ichiro Taniuchi.

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Yamashita, M., Taniuchi, I. Fine-tuning Notch1 by the stage-specific enhancer. Nat Immunol 23, 1509–1511 (2022). https://doi.org/10.1038/s41590-022-01341-9

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