Akin to adult stem cells, precursor exhausted T cells are hierarchically organized, with long-lived CD62L+ stem-like T cells at the apex of the system. The transcription factor c-Myb controls the formation, maintenance and therapeutic function of these cells, with important implications for their clinical utilization.
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L.G. is an inventor on a patent that describes methods for generating and isolating TSCM cells and on a patent that describes the use of c-Myb to enhance T cell therapy efficacy. L.G. has consulting agreements with Lyell Immunopharma, Advaxis Immunotherapies and Instil Bio, is on the scientific advisory boards of Poseida Therapeutics and Kiromic, and is a stockholder of Poseida Therapeutics. C.H. declares no competing interests.
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Heuser, C., Gattinoni, L. c-Myb redefines the hierarchy of stem-like T cells. Nat Immunol 23, 1405–1407 (2022). https://doi.org/10.1038/s41590-022-01319-7