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Translational regulation

tRNA methylation — a new level of control for T cell immunity

m1A58 is a common tRNA modification that can influence protein translational efficiency. Here Liu et al. reveal that tRNA methylation controls in vivo T cell activation by enhancing translation of the key transcription factor Myc.

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Fig. 1: Proposed model: m1A58 in tRNA selectively increases Myc mRNA translation to enhance T cell activation.

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Correspondence to Julia M. Marchingo.

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Marchingo, J.M. tRNA methylation — a new level of control for T cell immunity. Nat Immunol 23, 1401–1402 (2022). https://doi.org/10.1038/s41590-022-01317-9

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