Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

m1A tRNA modification facilitates rapid T cell proliferation

    Nature Immunology volume 23, pages 1408–1409 (2022)Cite this article

    Subjects

    During T cell activation, tRNA-m1A ‘writers’ TRMT61A and TRMT6 are upregulated to modify a group of early tRNA species and promote efficient translation of certain pre-cell-cycling proteins, thus ensuring rapid T cell proliferation and a timely adaptive immune response.

    This is a preview of subscription content, access via your institution

    Access options

    Buy article

    Get time limited or full article access on ReadCube.

    $32.00

    Buy

    All prices are NET prices.

    Fig. 1: TRMT61A controls T cell proliferation and function.

    References

    1. Zhu, J., Yamane, H. & Paul, W. E. Differentiation of effector CD4 T cell populations. Annu. Rev. Immunol. 28, 445–489 (2010). A review article that presents the fundamentals of CD4+ T cells.

      Article  CAS  Google Scholar 

    2. Schimmel, P. The emerging complexity of the tRNA world: mammalian tRNAs beyond protein synthesis. Nat. Rev. Mol. Cell Biol. 19, 45–58 (2018). A review article that presents the basics of tRNAs and tRNA modification.

      Article  CAS  Google Scholar 

    3. Tan, H. et al. Integrative proteomics and phosphoproteomics profiling reveals dynamic signaling networks and bioenergetics pathways underlying T cell activation. Immunity 46, 488–503 (2017). This study analyses the proteomic dynamics of T cell activation.

      Article  CAS  Google Scholar 

    4. Li, H. B. et al. m6A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways. Nature 548, 338–342 (2017). This paper reports the in vivo function of m6A mRNA modification during T cell activation and differentiation.

      Article  CAS  Google Scholar 

    5. Hwang, S. S. et al. mRNA destabilization by BTG1 and BTG2 maintains T cell quiescence. Science 367, 1255–1260 (2020). This study demonstrates that the transcription factors BTG1 and BTG2 protect global mRNA polyadenylate tail length and T cell quiescence.

      Article  CAS  Google Scholar 

    Download references

    Additional information

    Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

    This is a summary of: Liu, Y. et al. tRNA-m1A modification promotes T cell expansion via efficient MYC protein synthesis. Nat. Immunol. https://doi.org/10.1038/s41590-022-01301-3 (2022).

    Rights and permissions

    Reprints and Permissions

    About this article

    Verify currency and authenticity via CrossMark

    Cite this article

    m1A tRNA modification facilitates rapid T cell proliferation. Nat Immunol 23, 1408–1409 (2022). https://doi.org/10.1038/s41590-022-01302-2

    Download citation

    • Published:

    • Issue Date:

    • DOI: https://doi.org/10.1038/s41590-022-01302-2

    Search

    Advanced search

    Quick links

    Nature Briefing

    Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

    Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing