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m1A tRNA modification facilitates rapid T cell proliferation

During T cell activation, tRNA-m1A ‘writers’ TRMT61A and TRMT6 are upregulated to modify a group of early tRNA species and promote efficient translation of certain pre-cell-cycling proteins, thus ensuring rapid T cell proliferation and a timely adaptive immune response.

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Fig. 1: TRMT61A controls T cell proliferation and function.


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This is a summary of: Liu, Y. et al. tRNA-m1A modification promotes T cell expansion via efficient MYC protein synthesis. Nat. Immunol. (2022).

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m1A tRNA modification facilitates rapid T cell proliferation. Nat Immunol 23, 1408–1409 (2022).

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