Tissue-destructive fibroblasts in arthritis are driven by the transcription factor ETS1. Analysis of a cross-tissue, single-cell fibroblast dataset and genetic loss-of-function approaches further suggest that ETS1-expressing fibroblasts have a universal role in pathological tissue remodeling in multiple diseases, including arthritis, colitis and cancer.
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This is a summary of: Yan, M. et al. ETS1 governs pathological tissue-remodeling programs in disease-associated fibroblasts. Nat. Immunol. https://doi.org/10.1038/s41590-022-01285-0 (2022).
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ETS1 is a key transcription factor that drives RANKL-expressing, tissue-destructive fibroblasts. Nat Immunol 23, 1303–1304 (2022). https://doi.org/10.1038/s41590-022-01298-9