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STROMAL IMMUNOLOGY

A common activator of tissue-remodeling fibroblasts across tissues

ETS1 regulates tissue-remodeling properties of specific fibroblast subtypes in the synovium, gut and cancer and thus emerges as a novel cross-tissue therapeutic target for modulation of pathogenic fibroblast activation.

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Fig. 1: A possible dichotomy between ETS1 and PU.1 fibroblasts.

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Correspondence to Caroline Ospelt.

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Ospelt, C. A common activator of tissue-remodeling fibroblasts across tissues. Nat Immunol 23, 1295–1296 (2022). https://doi.org/10.1038/s41590-022-01294-z

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