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MECHANOIMMUNOLOGY

Mechanics drive lymph node expansion

Multistep mechanosensing of lymphocyte infiltration and proliferation by the remodeling stroma and matrix underlies the immensely rapid and massive tissue expansion by lymph nodes in response to immune challenge.

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Fig. 1: Mechanics-driven expansion of the reactive lymph node.

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Correspondence to Susan N. Thomas.

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Alapan, Y., Thomas, S.N. Mechanics drive lymph node expansion. Nat Immunol 23, 1139–1141 (2022). https://doi.org/10.1038/s41590-022-01277-0

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