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Glucocorticoids initiate regulatory T cell and stem-cell crosstalk to grow new hair

Instructed by locally increased levels of glucocorticoids in the skin after acute hair loss, regulatory T cells communicate with hair follicle stem cells by producing TGFβ3 to stimulate stem-cell proliferation and hair regrowth.

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Fig. 1: Local glucocorticoids instruct Treg cell–stem-cell crosstalk to facilitate hair growth.

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This is a summary of: Zheng, Y. et al. Glucocorticoid signaling and regulatory T cells cooperate to maintain the hair-follicle stem-cell niche. Nat. Immunol. https://doi.org/10.1038/s41590-022-01244-9 (2022)

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Glucocorticoids initiate regulatory T cell and stem-cell crosstalk to grow new hair. Nat Immunol 23, 1006–1007 (2022). https://doi.org/10.1038/s41590-022-01250-x

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