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TISSUE INFLAMMATION

When inflammation turns sour on T cells

Nature Immunology volume 23, pages 991–993 (2022)Cite this article

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Inflamed tissue has a special milieu, with hypoxia, high levels of metabolites from anaerobic glycolysis, and acidosis. Stimulation of a proton-activated receptor, TDAG8 (GPR65), in T cells has an important role in inflammatory bowel disease by balancing pro- and anti-inflammatory signals.

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Fig. 1: Proton-activated receptors acting in inflammatory bowel disease.

References

  1. GBD 2017 Inflammatory Bowel Disease Collaborators. Lancet Gastroenterol. Hepatol. 5, 17–30 (2020).

    Article  Google Scholar 

  2. Jostins, L. et al. Nature 491, 119–124 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Lassen, K. G. et al. Immunity 44, 1392–1405 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Tcymbarevich, I. V. et al. BMC Gastroenterol. 19, 2 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Chen, X. et al. Nat. Immunol. https://doi.org/10.1038/s41590-022-01231-0 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Imenez Silva, P. H. & Wagner, C. A. Pflugers Arch. 474, 487–504 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Eltzschig, H. K. & Carmeliet, P. N. Engl. J. Med. 364, 656–665 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Boedtkjer, E. & Pedersen, S. F. Annu. Rev. Physiol. 82, 103–126 (2020).

    Article  CAS  PubMed  Google Scholar 

  9. Cosin-Roger, J. et al. Nat. Commun. 8, 98 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  10. de Vallière, C. et al. Inflamm. Bowel Dis. 21, 1269–1281 (2015).

    PubMed  Google Scholar 

  11. Hutter, S. et al. J. Crohns Colitis 12, 1348–1358 (2018).

    PubMed  Google Scholar 

  12. Wang, Y. et al. J. Crohns Colitis 12, 355–368 (2018).

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

Work in the laboratory of the authors has been supported by the Swiss National Science Foundation (SNSF) and the SNSF-funded National Center for Competence in Research NCCR Kidney.CH.

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Authors and Affiliations

  1. Institute of Physiology, University of Zurich, Zurich, Switzerland

    Carsten A. Wagner & Pedro H. Imenez Silva

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  1. Carsten A. Wagner
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  2. Pedro H. Imenez Silva
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Correspondence to Carsten A. Wagner.

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Competing interests

C.A.W. has received honoraria from Ardelyx, Kyowa Kirin, Salmon Pharma, Advicenne and Medice not related to the work discussed here. P.H.I.S. has no competing interests.

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Wagner, C.A., Imenez Silva, P.H. When inflammation turns sour on T cells. Nat Immunol 23, 991–993 (2022). https://doi.org/10.1038/s41590-022-01241-y

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