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Long-term study of the human memory B cell pool reveals high stability and recurrent plasmablasts

A single-cell sequencing study shows that the human memory B cell repertoire is dominated by large IgM, IgG2 and IgA immunoglobulin families, whereas IgG1 families, including those specific for recall antigens, are of a small size. Multi-year analysis shows that memory B cell families are highly stable and that plasmablasts of T cell–independent and T cell–dependent isotypes are produced in a recurrent manner.

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Fig. 1: Clonal structure and dynamics of the human memory B cell pool.


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This is a summary of: Phad, G. E. et al. Clonal structure, stability and dynamics of human memory B cells and circulating plasmablasts. Nat. Immunol. (2021).

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Long-term study of the human memory B cell pool reveals high stability and recurrent plasmablasts. Nat Immunol 23, 1002–1003 (2022).

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