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THE INFLAMMASOME

Viral protein activates the NLRP1 inflammasome

Inflammasomes function as immune-signaling platforms that assemble following pathogen detection. Direct binding of a viral protein to NLRP1 and the disruption of a previously unknown autoinhibitory NRLP1 complex drive the activation of the NLRP1 inflammasome independently of the proteasome.

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Fig. 1: Proteasome-dependent and independent activation of NLRP1.

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Correspondence to Petr Broz.

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Hartenian, E., Broz, P. Viral protein activates the NLRP1 inflammasome. Nat Immunol 23, 822–824 (2022). https://doi.org/10.1038/s41590-022-01226-x

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  • DOI: https://doi.org/10.1038/s41590-022-01226-x

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