Intra-islet CD8+ T cells from a mouse model of type 1 diabetes exhibit an exhausted phenotype that differs from the canonical T cell exhaustion observed in cancer and chronic viral infection. Deletion of the inhibitory receptor LAG3 in these cells accelerated diabetes incidence and partially reversed this restrained phenotype.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Blank, C. U. et al. Defining 'T cell exhaustion'. Nat. Rev. Immunol. 19, 665–674 (2019). A comprehensive review summarizing almost 30 years of research into the developmental state of T cell exhaustion.
Grebinoski, S. & Vignali, D. A. A. Inhibitory receptor agonists: the future of autoimmune disease therapeutics? Curr. Opin. Immunol. 67, 1–9 (2020). A comprehensive review examining the current and future state of the development of immunotherapeutic IR agonists to treat autoimmune diseases, and the evidence supporting these efforts.
Bettini, M. et al. Cutting edge: accelerated autoimmune diabetes in the absence of LAG-3. J. Immunol. 187, 3493–3498 (2011). A research article that first sparked our interest in studying the role of LAG3 in limiting autoimmune diabetes.
Zhang, Q. et al. LAG3 limits regulatory T cell proliferation and function in autoimmune diabetes. Sci. Immunol. 2, eaah4569 (2017). A research article investigating the role of LAG3 in limiting regulatory T cell function in autoimmune diabetes.
Chen, Y.-G., Mathews, C. E. & Driver, J. P. The role of NOD mice in type 1 diabetes research: lessons from the past and recommendations for the future. Front. Endocrinol. https://doi.org/10.3389/fendo.2018.00051 (2018). A comprehensive review of the NOD mouse model of autoimmune diabetes and how it is used to enhance the understanding of T1D.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Grebinoski, S. et al. Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG3. Nat. Immunol. https://doi.org/10.1038/s41590-022-01210-5 (2022).
Rights and permissions
About this article
Cite this article
Defining an exhaustion-like program that restrains autoreactive CD8+ T cells. Nat Immunol 23, 832–833 (2022). https://doi.org/10.1038/s41590-022-01211-4
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41590-022-01211-4
