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NEUTROPHILS

Neutrophils guide pre-existing matrix into injured organs to initiate tissue repair

Nature Immunology volume 23, pages 472–473 (2022)Cite this article

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The formation of a provisional matrix is required for the onset of tissue repair. New research shows that neutrophils carry pre-existing matrix across organs into wounds, promoting fibroblast activation and scar formation.

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Fig. 1: Dynamics and mechanisms of neutrophil matrix transfer.

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Acknowledgements

The author would like to thank S. Z. Chong and J. L. L. Yao for critical reading of the manuscript. L.G.N. is supported by SIgN core funding. The author apologizes to the many colleagues whose contributions could not be discussed in this article.

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Authors and Affiliations

  1. Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), Biopolis, Singapore, Singapore

    Lai Guan Ng

  2. Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

    Lai Guan Ng

  3. National Skin Centre, Singapore, Singapore

    Lai Guan Ng

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  1. Lai Guan Ng
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Correspondence to Lai Guan Ng.

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Ng, L.G. Neutrophils guide pre-existing matrix into injured organs to initiate tissue repair. Nat Immunol 23, 472–473 (2022). https://doi.org/10.1038/s41590-022-01173-7

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