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Retention of immune cells in cribriform lymphatics is induced by neuroinflammation

Cribriform plate-resident lymphatic endothelial cells respond to neuroinflammatory signals by inducing functional changes that enhance the capture and presentation of antigens from the cerebrospinal fluid and promote leukocyte interactions within the brain-draining lymphatics.

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Fig. 1: The cribriform plate lymphatics are a prime site for drainage and immune cell crosstalk.


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This is a summary of: Hsu, M. et al. Neuroinflammation creates an immune regulatory niche at the meningeal lymphatic vasculature near the cribriform plate. Nat. Immunol. (2022)

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Retention of immune cells in cribriform lymphatics is induced by neuroinflammation. Nat Immunol 23, 483–484 (2022).

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