Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

IMMUNE SURVEILLANCE

γδ T cells monitor tissue health

Nature Immunology volume 23, pages 348–349 (2022)Cite this article

Subjects

Crosstalk between the dendritic epidermal γδ T cell (DETC) T cell receptor and Skint1 expressed by keratinocytes at steady state regulates epidermal barrier function and maintains DETC responsiveness.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Epidermal Skint1–DETC interactions maintain immunosurveillance and barrier function.

References

  1. Nielsen, M. M., Witherden, D. A. & Havran, W. L. Nat. Rev. Immunol. 17, 733–745 (2017).

    Article  CAS  Google Scholar 

  2. Jandke, A. et al. Nat. Commun. 11, 3769 (2020).

    Article  Google Scholar 

  3. Boyden, L. M. et al. Nat. Genet. 40, 656–662 (2008).

    Article  CAS  Google Scholar 

  4. McKenzie, D. R. et al. Nat. Immunol. https://doi.org/10.1038/s41590-021-01124-8 (2022).

    Article  PubMed  Google Scholar 

  5. Chodaczek, G., Papanna, V., Zal, M. A. & Zal, T. Nat. Immunol. 13, 272–282 (2012).

    Article  CAS  Google Scholar 

  6. Dalessandri, T., Crawford, G., Hayes, M., Castro Seoane, R. & Strid, J. Nat. Commun. 7, 12080 (2016).

    Article  CAS  Google Scholar 

  7. Matsue, H., Bergstresser, P. R. & Takashima, A. J. Immunol. 151, 6012–6019 (1993).

    CAS  PubMed  Google Scholar 

  8. MacLeod, A. S. et al. J. Immunol. 1950, 5695–5702 (2014).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, Department of Medicine, Ronald O. Perelman Department of Dermatology, and Perlmutter Cancer Center, New York University Langone Health, New York, NY, USA

    Ipsita Subudhi & Shruti Naik

Authors
  1. Ipsita Subudhi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Shruti Naik
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Shruti Naik.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Subudhi, I., Naik, S. γδ T cells monitor tissue health. Nat Immunol 23, 348–349 (2022). https://doi.org/10.1038/s41590-022-01139-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-022-01139-9

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing