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An anion channel for cyclic dinucleotides in T cells

LRRC8C is an essential component of volume-regulated anion channel (VRAC) in T cells. By mediating the transport of cGAMP, LRRC8C inhibits T cell function by activating STING and the tumor suppressor p53.

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Fig. 1: LRRC8C-containing VRAC channel suppresses T cell function by mediating cGAMP transport and activating STING and p53.


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Correspondence to Zhaozhu Qiu.

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Chu, J., Qiu, Z. An anion channel for cyclic dinucleotides in T cells. Nat Immunol 23, 157–158 (2022).

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