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CANCER IMMUNOLOGY

MHC-I presents: tumor surveillance in the epithelia by cell competition

When transformed cells emerge in an epithelium, their elevated class I MHC expression signals to normal neighboring epithelial cells, which respond by inducing their apical extrusion as a tumor-suppressive mechanism.

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Fig. 1: Transformed epithelial cells are eliminated by the surrounding healthy tissue.

References

  1. Ayakawa, S. et al. Nat. Immunol. https://doi.org/10.1038/s41590-021-01045-6 (2021).

  2. Kon, S. & Fujita, Y. Dev. Biol. 476, 112–116 (2021).

    Article  CAS  Google Scholar 

  3. Bowling, S., Lawlor, K. & Rodriguez, T. A. Development 146, dev167486 (2019).

    Article  CAS  Google Scholar 

  4. Kajita, M. et al. Nat. Commun. 5, 4428 (2014).

    Article  CAS  Google Scholar 

  5. Franceschi, R. T. & Xiao, G. J. Cell. Biochem. 88, 446–454 (2003).

    Article  CAS  Google Scholar 

  6. Takai, T. Immunology 115, 433–440 (2005).

    Article  CAS  Google Scholar 

  7. Meyer, S. N. et al. Science 346, 1258236 (2014).

    Article  CAS  Google Scholar 

  8. Germani, F., Hain, D., Sternlicht, D., Moreno, E. & Basler, K. eLife 7, e39939 (2018).

    Article  Google Scholar 

  9. Katsukawa, M., Ohsawa, S., Zhang, L., Yan, Y. & Igaki, T. Curr. Biol. 28, 1756–1767.e1756 (2018).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Ana Lima or Tristan A. Rodriguez.

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Lima, A., Rodriguez, T.A. MHC-I presents: tumor surveillance in the epithelia by cell competition. Nat Immunol 22, 1358–1360 (2021). https://doi.org/10.1038/s41590-021-01053-6

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