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Mitochondrial dysfunction in the erythroid compartment

The retention of erythroid mitochondria, a feature associated with impairments in the ubiquitin–proteasome system, is detected in a subset of pediatric patients with lupus and is associated with the type I interferon pathway.

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Fig. 1: Deficient mitochondrial removal and association with type I IFN responses.

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Correspondence to Mariana J. Kaplan.

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Kaplan, M.J. Mitochondrial dysfunction in the erythroid compartment. Nat Immunol 22, 1354–1355 (2021). https://doi.org/10.1038/s41590-021-01050-9

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  • DOI: https://doi.org/10.1038/s41590-021-01050-9

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