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RESIDENT MEMORY

Resident T cells seek the perfect place to work from home

CD8+ resident memory T (TRM) cells from different tissues form a heterogeneous population. Transforming growth factor (TGF)-β-independent CD103 TRM cells in the liver retain the ability to move to barrier tissues or return to secondary lymphoid organs.

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Fig. 1: Liver TRM cells possess the ability to relocate to the skin to become TGF-β-dependent TRM cells.

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Correspondence to Ian A. Cockburn.

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McNamara, H.A., Cockburn, I.A. Resident T cells seek the perfect place to work from home. Nat Immunol 22, 1076–1078 (2021). https://doi.org/10.1038/s41590-021-01003-2

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