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NEUTROPHILS

Neutrophil life in three acts: a production by different stage directors

Analysis of the transcriptional landscape of inflammatory neutrophils discloses specific transcription factor engagement at the bone marrow–to-blood and the blood-to-tissue transitions.

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Fig. 1: Neutrophils remodel their transcriptional landscape at the BM–blood and blood–tissue transitions.

References

  1. 1.

    Borregaard, N., Sørensen, O. E. & Theilgaard-Mönch, K. Trends Immunol. 28, 340–345 (2007).

    CAS  Article  Google Scholar 

  2. 2.

    Ecker, S. et al. Genome Biol. 18, 18 (2017).

    Article  Google Scholar 

  3. 3.

    Silvestre-Roig, C., Hidalgo, A. & Soehnlein, O. Blood 127, 2173–2181 (2016).

    CAS  Article  Google Scholar 

  4. 4.

    Ballesteros, I. et al. Cell 183, 1282–1297.e18 (2020).

    CAS  Article  Google Scholar 

  5. 5.

    Khoyratty, T. E. et al. Nat. Immunol. https://doi.org/10.1038/s41590-021-00968-4 (2021).

    Article  PubMed  Google Scholar 

  6. 6.

    Grassi, L. et al. Cell Rep. 24, 2784–2794 (2018).

    CAS  Article  Google Scholar 

  7. 7.

    Grieshaber-Bouyer, R. et al. Nat. Commun. 12, 2856 (2021).

    CAS  Article  Google Scholar 

  8. 8.

    Xie, X. et al. Nat. Immunol. 21, 1119–1133 (2020).

    CAS  Article  Google Scholar 

  9. 9.

    Bajrami, B. et al. J. Exp. Med. 213, 1999–2018 (2016).

    CAS  Article  Google Scholar 

  10. 10.

    Ferraro, B. et al. J. Am. Coll. Cardiol. 73, 2990–3002 (2019).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Raphael Chevre or Oliver Soehnlein.

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R.C. declares no competing interests. O.S. receives funding from Novo Nordisk to study the potential of chronopharmacology for the treatment of atherosclerosis; he is also inventor on patents dealing with chemokine signaling and histones in inflammation.

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Chevre, R., Soehnlein, O. Neutrophil life in three acts: a production by different stage directors. Nat Immunol 22, 1072–1074 (2021). https://doi.org/10.1038/s41590-021-00997-z

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