Analysis of the transcriptional landscape of inflammatory neutrophils discloses specific transcription factor engagement at the bone marrow–to-blood and the blood-to-tissue transitions.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Borregaard, N., Sørensen, O. E. & Theilgaard-Mönch, K. Trends Immunol. 28, 340–345 (2007).
Ecker, S. et al. Genome Biol. 18, 18 (2017).
Silvestre-Roig, C., Hidalgo, A. & Soehnlein, O. Blood 127, 2173–2181 (2016).
Ballesteros, I. et al. Cell 183, 1282–1297.e18 (2020).
Khoyratty, T. E. et al. Nat. Immunol. https://doi.org/10.1038/s41590-021-00968-4 (2021).
Grassi, L. et al. Cell Rep. 24, 2784–2794 (2018).
Grieshaber-Bouyer, R. et al. Nat. Commun. 12, 2856 (2021).
Xie, X. et al. Nat. Immunol. 21, 1119–1133 (2020).
Bajrami, B. et al. J. Exp. Med. 213, 1999–2018 (2016).
Ferraro, B. et al. J. Am. Coll. Cardiol. 73, 2990–3002 (2019).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
R.C. declares no competing interests. O.S. receives funding from Novo Nordisk to study the potential of chronopharmacology for the treatment of atherosclerosis; he is also inventor on patents dealing with chemokine signaling and histones in inflammation.
Rights and permissions
About this article
Cite this article
Chevre, R., Soehnlein, O. Neutrophil life in three acts: a production by different stage directors. Nat Immunol 22, 1072–1074 (2021). https://doi.org/10.1038/s41590-021-00997-z
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41590-021-00997-z
This article is cited by
-
In vivo monitoring of neutrophil trafficking to sites of injury
Nature Cardiovascular Research (2023)
-
Induction of functional neutrophils from mouse fibroblasts by thymidine through enhancement of Tet3 activity
Cellular & Molecular Immunology (2022)