Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Neutrophil life in three acts: a production by different stage directors

Analysis of the transcriptional landscape of inflammatory neutrophils discloses specific transcription factor engagement at the bone marrow–to-blood and the blood-to-tissue transitions.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: Neutrophils remodel their transcriptional landscape at the BM–blood and blood–tissue transitions.


  1. 1.

    Borregaard, N., Sørensen, O. E. & Theilgaard-Mönch, K. Trends Immunol. 28, 340–345 (2007).

    CAS  Article  Google Scholar 

  2. 2.

    Ecker, S. et al. Genome Biol. 18, 18 (2017).

    Article  Google Scholar 

  3. 3.

    Silvestre-Roig, C., Hidalgo, A. & Soehnlein, O. Blood 127, 2173–2181 (2016).

    CAS  Article  Google Scholar 

  4. 4.

    Ballesteros, I. et al. Cell 183, 1282–1297.e18 (2020).

    CAS  Article  Google Scholar 

  5. 5.

    Khoyratty, T. E. et al. Nat. Immunol. (2021).

    Article  PubMed  Google Scholar 

  6. 6.

    Grassi, L. et al. Cell Rep. 24, 2784–2794 (2018).

    CAS  Article  Google Scholar 

  7. 7.

    Grieshaber-Bouyer, R. et al. Nat. Commun. 12, 2856 (2021).

    CAS  Article  Google Scholar 

  8. 8.

    Xie, X. et al. Nat. Immunol. 21, 1119–1133 (2020).

    CAS  Article  Google Scholar 

  9. 9.

    Bajrami, B. et al. J. Exp. Med. 213, 1999–2018 (2016).

    CAS  Article  Google Scholar 

  10. 10.

    Ferraro, B. et al. J. Am. Coll. Cardiol. 73, 2990–3002 (2019).

    CAS  Article  Google Scholar 

Download references

Author information



Corresponding authors

Correspondence to Raphael Chevre or Oliver Soehnlein.

Ethics declarations

Competing interests

R.C. declares no competing interests. O.S. receives funding from Novo Nordisk to study the potential of chronopharmacology for the treatment of atherosclerosis; he is also inventor on patents dealing with chemokine signaling and histones in inflammation.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Chevre, R., Soehnlein, O. Neutrophil life in three acts: a production by different stage directors. Nat Immunol 22, 1072–1074 (2021).

Download citation


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing