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TUMOR IMMUNOLOGY

Tpt1 the balance toward immunosuppression upon cell death

By engaging Toll-like receptor 2, translationally controlled tumor protein (TCTP) released from necrotic tumor cells can switch on an immunosuppressive network of monocytic and polymorphonuclear myeloid-derived suppressor cells to block antitumor immunity.

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Fig. 1: TCTP has immunomodulatory activity when released from necrotic cancer cells.

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Correspondence to Yuting Ma.

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Ma, Y. Tpt1 the balance toward immunosuppression upon cell death. Nat Immunol 22, 940–942 (2021). https://doi.org/10.1038/s41590-021-00986-2

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