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Tpt1 the balance toward immunosuppression upon cell death

By engaging Toll-like receptor 2, translationally controlled tumor protein (TCTP) released from necrotic tumor cells can switch on an immunosuppressive network of monocytic and polymorphonuclear myeloid-derived suppressor cells to block antitumor immunity.

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Fig. 1: TCTP has immunomodulatory activity when released from necrotic cancer cells.


  1. Galluzzi, L., Buqué, A., Kepp, O., Zitvogel, L. & Kroemer, G. Nat. Rev. Immunol. 17, 97–111 (2017).

    CAS  Article  Google Scholar 

  2. Ma, Y., Pitt, J. M., Li, Q. & Yang, H. Immunol. Rev. 280, 194–206 (2017).

    CAS  Article  Google Scholar 

  3. Hangai, S. et al. Nat Immunol. (2021).

  4. Yee, P. P. et al. Nat. Commun. 11, 5424 (2020).

    Article  Google Scholar 

  5. Yatim, N., Cullen, S. & Albert, M. L. Nat. Rev. Immunol. 17, 262–275 (2017).

    CAS  Article  Google Scholar 

  6. Ahrens, S. et al. Immunity 36, 635–645 (2012).

    CAS  Article  Google Scholar 

  7. Hangai, S. et al. Proc. Natl Acad. Sci. USA 113, 3844–3849 (2016).

    CAS  Article  Google Scholar 

  8. Seifert, L. et al. Nature 532, 245–249 (2016).

    CAS  Article  Google Scholar 

  9. Bommer, U.-A. Results Probl. Cell Differ. 64, 69–126 (2017).

    CAS  Article  Google Scholar 

  10. Bommer, U.-A. et al. Cell Commun. Signal. 15, 9 (2017).

    Article  Google Scholar 

  11. Sterle, H. A. et al. Br. J. Cancer 120, 128–138 (2019).

    CAS  Article  Google Scholar 

  12. Yang, X. D. et al. Nat. Med. 17, 87–95 (2011).

    CAS  Article  Google Scholar 

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Correspondence to Yuting Ma.

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Ma, Y. Tpt1 the balance toward immunosuppression upon cell death. Nat Immunol 22, 940–942 (2021).

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