Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

IMMUNE EXHAUSTION

T cell exhaustion—a memory locked behind scars

Following clearance of chronic infections, virus-specific CD8+ T cells recover a subset of memory-related transcriptome features. Yet their unique open chromatin landscape largely reflects an exhausted or dysfunctional state, limiting their protective memory potential.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: Epigenetic scars restrain exhausted CD8+ T cells from acquiring functional memory potential after antigen stimulation is eliminated.

References

  1. 1.

    Thucydides. History of the Peloponnesian War (transl. Jowett, B.) Book II, Ch. 51. (Clarendon Press, 1881).

  2. 2.

    Hashimoto, M. et al. Annu. Rev. Med. 69, 301–318 (2018).

    CAS  Article  Google Scholar 

  3. 3.

    Saadey, A., Yousif, A. & Ghoneim, H. E. in Cancer Immunology and Immunotherapy (ed. Amiji, M.) Ch. 7 (Elsevier, in the press).

  4. 4.

    Hensel, N. et al. Nat. Immunol. 22, 229–239 (2021).

    CAS  Article  Google Scholar 

  5. 5.

    Tonnerre, P. et al. Nat. Immunol. https://doi.org/10.1038/s41590-021-00982-6 (2021).

    Article  Google Scholar 

  6. 6.

    Yates, K. B. et al. Nat. Immunol. https://doi.org/10.1038/s41590-021-00979-1 (2021).

    Article  Google Scholar 

  7. 7.

    Abdel-Hakeem, M. S. et al. Nat. Immunol. https://doi.org/10.1038/s41590-021-00975-5 (2021).

    Article  Google Scholar 

  8. 8.

    Holmes, J. A., Rutledge, S. M. & Ching, R. T. Lancet 393, 1392–1394 (2019).

    Article  Google Scholar 

  9. 9.

    Kelsey, G., Stegle, O. & Reik, W. Science 358, 69–75 (2017).

    CAS  Article  Google Scholar 

  10. 10.

    Youngblood, B. et al. Nature 552, 404–409 (2017).

    CAS  Article  Google Scholar 

  11. 11.

    Page, N. et al. Nat. Commun. 12, 1009 (2021).

    CAS  Article  Google Scholar 

  12. 12.

    Gattinoni, L., Speiser, D. E., Lichterfeld, M. & Bonini, C. Nat. Med. 23, 18–27 (2017).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Hazem E. Ghoneim.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Yousif, A., Ghoneim, H.E. T cell exhaustion—a memory locked behind scars. Nat Immunol 22, 938–940 (2021). https://doi.org/10.1038/s41590-021-00977-3

Download citation

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing