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T cell exhaustion—a memory locked behind scars

Following clearance of chronic infections, virus-specific CD8+ T cells recover a subset of memory-related transcriptome features. Yet their unique open chromatin landscape largely reflects an exhausted or dysfunctional state, limiting their protective memory potential.

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Fig. 1: Epigenetic scars restrain exhausted CD8+ T cells from acquiring functional memory potential after antigen stimulation is eliminated.


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Correspondence to Hazem E. Ghoneim.

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The authors declare no competing interests.

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Yousif, A., Ghoneim, H.E. T cell exhaustion—a memory locked behind scars. Nat Immunol 22, 938–940 (2021).

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