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Inflammatory stromal cells in the myeloma microenvironment

Single-cell RNA sequencing identifies an inflammatory subpopulation of mesenchymal stromal cells in patients with multiple myeloma.

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Fig. 1: Model of the interaction between iMSCs and tumor and immune cells.


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Correspondence to Irene M. Ghobrial.

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Competing interests

R.S.P. has no competing interests to disclose. N.J.H. is a consultant for Constellation Pharmaceuticals. I.M.G has a consulting and advisory role with Celgene, Takeda, Bristol-Myers Squibb, Genentech, Janssen Pharmaceuticals and Amgen and has received research funding/honoraria from Celgene, Takeda, Bristol-Myers Squibb, Janssen Pharmaceuticals and Amgen. G.G. receives research funds from IBM and Pharmacyclics and is an inventor on patent applications related to MuTect, ABSOLUTE, MutSig, MSMuTect, MSMutSig, MSIdetect, POLYSOLVER and TensorQTL. G.G. is a founder, consultant and holds privately held equity in Scorpion Therapeutics.

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Sklavenitis-Pistofidis, R., Haradhvala, N.J., Getz, G. et al. Inflammatory stromal cells in the myeloma microenvironment. Nat Immunol 22, 677–678 (2021).

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