Chromatin undergoes extensive reprogramming during immune cell differentiation. Histone clipping, an underexplored epigenetic mechanism, ensures precise macrophage development and function and is now found to be dysregulated in autoinflammatory disease.
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The authors declare no competing financial interests.
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Kragesteen, B.K., Amit, I. Heads or tails: histone tail clipping regulates macrophage activity. Nat Immunol 22, 678–680 (2021). https://doi.org/10.1038/s41590-021-00941-1
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