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Heads or tails: histone tail clipping regulates macrophage activity

Chromatin undergoes extensive reprogramming during immune cell differentiation. Histone clipping, an underexplored epigenetic mechanism, ensures precise macrophage development and function and is now found to be dysregulated in autoinflammatory disease.

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Fig. 1: The dynamics of histone H3 tail clipping are important in the epigenetic regulation of monocyte-to-macrophage differentiation.


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Correspondence to Bjørt K. Kragesteen or Ido Amit.

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Kragesteen, B.K., Amit, I. Heads or tails: histone tail clipping regulates macrophage activity. Nat Immunol 22, 678–680 (2021).

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