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STROMAL IMMUNOLOGY

Lymphoid stromal cells proGrem dendritic cell homeostasis

Nature Immunology volume 22, pages 541–543 (2021)Cite this article

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Single-cell technologies reveal the building blocks of secondary lymphoid organs, identifying Grem1+ fibroblastic reticular cells (FRCs) as critical niche cells that contribute to resident dendritic cell homeostasis and T cell immunity.

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Fig. 1: Grem1+ FRCs build a niche for DC homeostasis and T cell immunity.

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Acknowledgements

A.P.B. is supported by a Marie-Skłodowska-Curie fellowship (EU project 898090). Research in the Gerner laboratory is supported by NIH grants R01AI134713, R21AI142667, R01AI1134246, 75N93019C00070, T32AI106677 and T32GM007270; the National Science Foundation (NSF DGE-1762114); the Washington Research Foundation postdoctoral fellowship; and research funds from Roche Glycart AG.

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Authors and Affiliations

  1. Laboratory of Immunoregulation and Mucosal Immunology, VIB-UGhent Center for Inflammation Research, Ghent, Belgium

    Antonio P. Baptista

  2. Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium

    Antonio P. Baptista

  3. Department of Immunology, University of Washington School of Medicine, Seattle, WA, USA

    Michael Y. Gerner

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  1. Antonio P. Baptista
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  2. Michael Y. Gerner
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Correspondence to Antonio P. Baptista or Michael Y. Gerner.

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Baptista, A.P., Gerner, M.Y. Lymphoid stromal cells proGrem dendritic cell homeostasis. Nat Immunol 22, 541–543 (2021). https://doi.org/10.1038/s41590-021-00924-2

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