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Experience counts in the malaria response

A systems immunology analysis of controlled human malaria infections in Africans who were malaria experienced and Europeans who were malaria naive yields new insights into old questions of malaria immunity.

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Fig. 1: Systems analysis of CHMI in African and European volunteers.


  1. 1.

    Moncunill, G. et al. Sci. Transl. Med. 12, eaay8924 (2020).

    CAS  Article  Google Scholar 

  2. 2.

    Tran, T. M. et al. Immunity 51, 750–765.e10 (2019).

    CAS  Article  Google Scholar 

  3. 3.

    de Jong, S. E. et al. Nat. Immunol. (2021).

    Article  PubMed  Google Scholar 

  4. 4.

    Crompton, P. D. et al. Annu. Rev. Immunol. 32, 157–187 (2014).

    CAS  Article  Google Scholar 

  5. 5.

    Langhorne, J., Ndungu, F. M., Sponaas, A.-M. & Marsh, K. Nat. Immunol. 9, 725–732 (2008).

    CAS  Article  Google Scholar 

  6. 6.

    Truong, K.-L. et al. Nat. Commun. 10, 2263 (2019).

    Article  Google Scholar 

  7. 7.

    Teirlinck, A. C. et al. PLoS Pathog. 7, e1002389 (2011).

    CAS  Article  Google Scholar 

  8. 8.

    Portugal, S. et al. Elife 4, e07218 (2015).

    Article  Google Scholar 

  9. 9.

    Ishizuka, A. S. et al. Nat. Med. 22, 614–623 (2016).

    CAS  Article  Google Scholar 

  10. 10.

    Zaidi, I. et al. J. Immunol. 199, 3781–3788 (2017).

    CAS  Article  Google Scholar 

  11. 11.

    Tsang, J. S. et al. Trends Immunol. 41, 457–465 (2020).

    CAS  Article  Google Scholar 

  12. 12.

    De Filippo, C. et al. Proc. Natl Acad. Sci. USA 107, 14691–14696 (2010).

    Article  Google Scholar 

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The authors would like to thank Austin J. Athman (Visual Medical Arts, National Institute of Allergy and Infectious Diseases, National Institutes of Health) for assistance with creating the illustration in Fig. 1.

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Correspondence to Tuan M. Tran.

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The authors declare no competing interests.

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Holla, P., Tran, T.M. Experience counts in the malaria response. Nat Immunol 22, 537–539 (2021).

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