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MYELODYSPLASTIC SYNDROME

There won’T be blood

Nature Immunology volume 22, pages 396–397 (2021)Cite this article

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Riok2 haploinsufficiency leads to aberrant TH22 skewing and interleukin-22-mediated erythroid dysfunction.

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Fig. 1: 5q–-mediated Riok2 haploinsufficiency leads to aberrant TH22 skewing and interleukin-22-mediated apoptosis of IL-22RA1+ erythroid precursors, driving 5q– MDS–related anemia.

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Authors and Affiliations

  1. Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada

    Mark Gower

  2. Department of Immunology, University of Toronto, Toronto, Ontario, Canada

    Mark Gower

  3. Department of Medical Oncology, Yale School of Medicine, New Haven, CT, USA

    Gena Foster

  4. Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA

    Gena Foster

  5. Princess Margaret Cancer Centre, University Health Network Toronto, Ontario, Canada

    Anastasia N. Tikhonova

Authors
  1. Mark Gower
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  2. Gena Foster
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  3. Anastasia N. Tikhonova
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Correspondence to Anastasia N. Tikhonova.

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Gower, M., Foster, G. & Tikhonova, A.N. There won’T be blood. Nat Immunol 22, 396–397 (2021). https://doi.org/10.1038/s41590-021-00893-6

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