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MYELODYSPLASTIC SYNDROME

There won’T be blood

Riok2 haploinsufficiency leads to aberrant TH22 skewing and interleukin-22-mediated erythroid dysfunction.

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Fig. 1: 5q-mediated Riok2 haploinsufficiency leads to aberrant TH22 skewing and interleukin-22-mediated apoptosis of IL-22RA1+ erythroid precursors, driving 5q MDS–related anemia.

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Correspondence to Anastasia N. Tikhonova.

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Gower, M., Foster, G. & Tikhonova, A.N. There won’T be blood. Nat Immunol 22, 396–397 (2021). https://doi.org/10.1038/s41590-021-00893-6

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