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HIV INFECTION

Targeting mitochondria to beat HIV-1

Nature Immunology volume 22, pages 398–399 (2021)Cite this article

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HIV-1 infection of CD4+ T cells triggers the interaction of the mitochondrial proteins NLRX1 and FASTKD5 to promote oxidative phosphorylation, leading to increased viral replication. It has now been shown that this process can be blocked by metformin.

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Fig. 1: HIV-1 infection increases the expression of NLRX1, which directly interacts with FASTKD5 to promote OXPHOS and viral replication.

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Authors and Affiliations

  1. School of Biochemistry and Immunology, Trinity College Dublin, Trinity Biomedical Sciences Institute, Dublin, Ireland

    Emily A. Day & Luke A. J. O’Neill

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  1. Emily A. Day
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  2. Luke A. J. O’Neill
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Correspondence to Luke A. J. O’Neill.

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The authors declare no competing interests.

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Day, E.A., O’Neill, L.A.J. Targeting mitochondria to beat HIV-1. Nat Immunol 22, 398–399 (2021). https://doi.org/10.1038/s41590-021-00881-w

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