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γδ T cells burst malaria’s bubble

Nature Immunology volume 22, pages 270–272 (2021)Cite this article

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New research demonstrates that γδ T cells recognize Plasmodium-infected erythrocytes via interaction of the T cell antigen receptor with the phosphoantigen sensor BTN3A1 and subsequently destroy infected cells through either cytotoxic molecule secretion or antibody-dependent phagocytosis.

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Fig. 1: γδ2 T cells target Plasmodium-infected erythrocytes for destruction.

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Authors and Affiliations

  1. Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA, USA

    Mitchell N. Lefebvre & John T. Harty

  2. Department of Pathology, University of Iowa, Iowa City, IA, USA

    John T. Harty

Authors
  1. Mitchell N. Lefebvre
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  2. John T. Harty
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Correspondence to John T. Harty.

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Lefebvre, M.N., Harty, J.T. γδ T cells burst malaria’s bubble. Nat Immunol 22, 270–272 (2021). https://doi.org/10.1038/s41590-021-00879-4

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