Brain tumors respire more oxygen, causing a hypoxic microenvironment that impairs innate γδ T cell–mediated antitumor activity. Reducing oxygen consumption by brain tumors or inhibiting hypoxia-inducible factor-1α in γδ T cells reinvigorates γδ T cell tumor-killing activity, leading to prolonged survival in brain-tumor-bearing mice.
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Yan, J. Antitumor γδ T cells need oxygen to function. Nat Immunol 22, 268–269 (2021). https://doi.org/10.1038/s41590-021-00874-9
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DOI: https://doi.org/10.1038/s41590-021-00874-9
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