Two studies reveal a role for the transcriptional regulator BATF3 as a T cell–intrinsic factor mediating effective memory responses. This finding opens future avenues of investigation and opportunities to enhance cellular immunotherapy.
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References
June, C. H., O’Connor, R. S., Kawalekar, O. U., Ghassemi, S. & Milone, M. C. Science 359, 1361–1365 (2018).
Ataide, M. A. et al. Nat. Immunol. https://doi.org/10.1038/s41590-020-0786-2 (2020).
Qiu, Z., Khairallah, C., Romanov, G. & Sheridan, B. S. J. Immunol. 205, 901–906 (2020).
Cui, W. & Kaech, S. M. Immunol. Rev. 236, 151–166 (2010).
Hildner, K. et al. Science 322, 1097–1100 (2008).
Ferris, S. T. et al. Nature https://doi.org/10.1038/s41586-020-2611-3 (2020).
Papalexi, E. & Satija, R. Nat. Rev. Immunol. 18, 35–45 (2018).
Kelsey, G., Stegle, O. & Reik, W. Science 358, 69–75 (2017).
Neelapu, S. S. et al. N. Engl. J. Med. 377, 2531–2544 (2017).
Park, J. H. et al. N. Engl. J. Med. 378, 449–459 (2018).
Lynn, R. C. et al. Nature 576, 293–300 (2019).
Stadtmauer, E. A. et al. Science 367, eaba7365 (2020).
Acknowledgements
C.A.L. is supported by a Stanford Science Fellowship. A.T.S. is supported by a Parker Bridge Scholar Award from the Parker Institute for Cancer Immunotherapy and a Career Award for Medical Scientists from the Burroughs Wellcome Fund.
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A.T.S. is a scientific founder of Immunai and receives research funding from Arsenal Biosciences.
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Lareau, C.A., Satpathy, A.T. An old BATF’s new T-ricks. Nat Immunol 21, 1309–1310 (2020). https://doi.org/10.1038/s41590-020-0796-0
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DOI: https://doi.org/10.1038/s41590-020-0796-0