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HUMORAL IMMUNITY

NR4As apply brakes on the B cell response

Nature Immunology volume 21, pages 1137–1139 (2020)Cite this article

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To trigger an adequate humoral immune response while ensuring self-tolerance, B cell activation is tightly controlled. A new study indicates that an NR4A-enforced built-in brake fine-tunes the early phase of transcriptional reprogramming induced by BCR stimulation.

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Fig. 1: Transient induction of NR4A proteins controls B cell response.

References

  1. Tan, C. et al. Nat. Immunol. https://doi.org/10.1038/s41590-020-0765-7 (2020).

  2. Winoto, A. & Littman, D. R. Cell 109, (Suppl.) S57–S66 (2002).

  3. Sekiya, T. et al. Nat. Immunol. 14, 230–237 (2013).

    Article  CAS  Google Scholar 

  4. Heinzel, S. et al. Nat. Immunol. 18, 96–103 (2017).

    Article  CAS  Google Scholar 

  5. Cyster, J. G. & Allen, C. D. C. Cell 177, 524–540 (2019).

    Article  CAS  Google Scholar 

  6. Shiow, L. R. et al. Nature 440, 540–544 (2006).

    Article  CAS  Google Scholar 

  7. Taub, D. D., Conlon, K., Lloyd, A. R., Oppenheim, J. J. & Kelvin, D. J. Science 260, 355–358 (1993).

    Article  CAS  Google Scholar 

  8. Molon, B. et al. Nat. Immunol. 6, 465–471 (2005).

    Article  CAS  Google Scholar 

  9. Liu, X. et al. Nature 567, 525–529 (2019).

    Article  CAS  Google Scholar 

  10. Tan, C. et al. J. Immunol. 202, 2907–2923 (2019).

    Article  CAS  Google Scholar 

  11. Jellusova, J. Curr. Opin. Immunol. 63, 21–28 (2020).

    Article  CAS  Google Scholar 

  12. Paus, D. et al. J. Exp. Med. 203, 1081–1091 (2006).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Campus-Vienna-Biocenter 1, Vienna, Austria

    Louisa Hill & Tanja A. Schwickert

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  1. Louisa Hill
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  2. Tanja A. Schwickert
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Correspondence to Tanja A. Schwickert.

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The authors declare no competing interests.

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Hill, L., Schwickert, T.A. NR4As apply brakes on the B cell response. Nat Immunol 21, 1137–1139 (2020). https://doi.org/10.1038/s41590-020-0775-5

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