Antigen escape by solid tumors has limited the efficacy of genetically modified T cells. T cells engineered to secrete the cytokine Flt3L induce the activation of endogenous T cells, enabling a broader repertoire of tumor antigens to be targeted via the expansion of intratumoral antigen presenting cells, significantly improving tumor responses.
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References
Brown, C. E. & Mackall, C. L. Nat. Rev. Immunol. 19, 73–74 (2019).
Jamal-Hanjani, M. et al. N. Engl. J. Med. 376, 2109–2121 (2017).
Lai, J. et al. Nat. Immunol. https://doi.org/10.1038/s41590-020-0676-7 (2020).
Vanderlugt, C. L. & Miller, S. D. Nat. Rev. Immunol. 2, 85–95 (2002).
Schreiber, R. D., Old, L. J. & Smyth, M. J. Science 331, 1565–1570 (2011).
Joshi, K. et al. Nat. Med. 25, 1549–1559 (2019).
Gubin, M. M. et al. Nature 515, 577–581 (2014).
Maude, S. L. et al. N. Engl. J. Med. 378, 439–448 (2018).
Park, J. H. et al. N. Engl. J. Med. 378, 449–459 (2018).
Shalabi, H. et al. Haematologica 103, e215–e218 (2018).
Majzner, R. G. & Mackall, C. L. Cancer Discov. 8, 1219–1226 (2018).
Rafiq, S., Hackett, C. S. & Brentjens, R. J. Nat. Rev. Clin. Oncol. 17, 147–167 (2020).
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Morris, E.C. Engineered T cells Flt around their targets. Nat Immunol 21, 831–832 (2020). https://doi.org/10.1038/s41590-020-0740-3
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DOI: https://doi.org/10.1038/s41590-020-0740-3
