IMMUNOTHERAPY

Engineered T cells Flt around their targets

Antigen escape by solid tumors has limited the efficacy of genetically modified T cells. T cells engineered to secrete the cytokine Flt3L induce the activation of endogenous T cells, enabling a broader repertoire of tumor antigens to be targeted via the expansion of intratumoral antigen presenting cells, significantly improving tumor responses.

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Fig. 1: Schematic representation of antitumor immunity generated by adoptively transferred gene-modified T cells (CAR or TCR T cells) with or without modification additional to secreted FLt3L.

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Correspondence to Emma C. Morris.

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Morris, E.C. Engineered T cells Flt around their targets. Nat Immunol 21, 831–832 (2020). https://doi.org/10.1038/s41590-020-0740-3

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