Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Captain GBP1: inflammasomes assemble, pyroptotic endgame

A Publisher Correction to this article was published on 10 September 2020

This article has been updated

Guanylate-binding proteins (GBPs) promote immune defenses against infectious agents. Two studies reveal that GBP1 directly binds to cytosolic lipopolysaccharide (LPS), bringing caspase-4 to the surface of bacteria to induce pyroptosis.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: GBP1 binds to cytosolic LPS and initiates the assembly of a signaling platform stabilized by GBP2–4 for the recruitment and activation of caspase-4.

Change history

  • 10 September 2020

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.


  1. Kim, B.-H. et al. Nat. Immunol. 17, 481–489 (2016).

    CAS  Article  Google Scholar 

  2. Wandel, M. P. et al. Nat. Immunol. (2020).

    Article  PubMed  Google Scholar 

  3. Santos, J. C. et al. Nat. Commun. (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Shi, J. et al. Nature 514, 187–192 (2014).

    CAS  Article  Google Scholar 

  5. Broz, P. et al. Nature 490, 288–291 (2012).

    CAS  Article  Google Scholar 

  6. Gurung, P. et al. J. Biol. Chem. 287, 34474–34483 (2012).

    CAS  Article  Google Scholar 

  7. Rathinam, V. A. et al. Cell 150, 606–619 (2012).

    CAS  Article  Google Scholar 

  8. Meunier, E. et al. Nature 509, 366–370 (2014).

    CAS  Article  Google Scholar 

  9. Man, S. M. et al. Nat. Immunol. 16, 467–475 (2015).

    CAS  Article  Google Scholar 

  10. Meunier, E. et al. Nat. Immunol. 16, 476–484 (2015).

    CAS  Article  Google Scholar 

  11. Fisch, D. et al. EMBO J. 38, e100926 (2019).

    Article  Google Scholar 

  12. Kutsch, M. et al. EMBO J. 39, e104926 (2020).

    CAS  Article  Google Scholar 

  13. Knodler, L. A. et al. Cell Host Microbe 16, 249–256 (2014).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Si Ming Man.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Feng, S., Man, S.M. Captain GBP1: inflammasomes assemble, pyroptotic endgame. Nat Immunol 21, 829–830 (2020).

Download citation

  • Published:

  • Issue Date:

  • DOI:

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing