Quantitative systems-level proteomics is cleverly used to reveal a dynamic program of protein turnover in naive and memory CD4+ T cells that, alongside a stockpile of metabolic protein machinery, poises the cells for activation.
This is a preview of subscription content, access via your institution
Open Access articles citing this article.
Cellular & Molecular Immunology Open Access 04 January 2022
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
Prices may be subject to local taxes which are calculated during checkout
Wolf, T. et al. Nat. Immunol. https://doi.org/10.1038/s41590-020-0714-5 (2020).
Geiger, R. et al. Cell 167, 829–842.e13 (2016).
Howden, A. J. M. et al. Nat. Immunol. 20, 1542–1554 (2019).
Tan, H. et al. Immunity 46, 488–503 (2017).
Voisinne, G. et al. Nat. Immunol. 20, 1530–1541 (2019).
Ricciardi, S. et al. Cell Metab. 28, 895–906.e5 (2018); erratum 28, 961 (2018).
Russ, B. E. et al. Immunity 41, 853–865 (2014).
Salerno, F. et al. Nat. Immunol. 19, 828–837 (2018).
Marchingo, J. M., Sinclair, L. V., Howden, A. J. & Cantrell, D. A. Elife 9, e53725 (2020).
Merkley, S. D., Chock, C. J., Yang, X. O., Harris, J. & Castillo, E. F. Front. Immunol. 9, 2914 (2018).
Macallan, D. C., Busch, R. & Asquith, B. Curr. Opin. Syst. Biol. 18, 77–86 (2019).
About this article
Cite this article
Marchingo, J.M., Cantrell, D.A. The active inner life of naive T cells. Nat Immunol 21, 827–828 (2020). https://doi.org/10.1038/s41590-020-0726-1
This article is cited by
Cellular & Molecular Immunology (2022)