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IMMUNE CELL PROTEOMICS

The active inner life of naive T cells

Quantitative systems-level proteomics is cleverly used to reveal a dynamic program of protein turnover in naive and memory CD4+ T cells that, alongside a stockpile of metabolic protein machinery, poises the cells for activation.

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Fig. 1: Translational dynamics and protein synthetic capacity of naive and activating T cells.

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Correspondence to Doreen A. Cantrell.

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Marchingo, J.M., Cantrell, D.A. The active inner life of naive T cells. Nat Immunol 21, 827–828 (2020). https://doi.org/10.1038/s41590-020-0726-1

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