RESIDENT MEMORY

Long-‘Trm’ protection of the CNS

A new report finds that peripheral immunization generates tissue-resident memory CD8+ T cells in the central nervous system that provide robust protection against local infection.

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Fig. 1: Tissue-resident memory T cell formation in the central nervous system.

References

  1. 1.

    Mundt, S., Greter, M., Flügel, A. & Becher, B. Trends Neurosci. 42, 667–679 (2019).

    Article  CAS  Google Scholar 

  2. 2.

    Klein, R. S. & Hunter, C. A. Immunity 46, 891–909 (2017).

    Article  CAS  Google Scholar 

  3. 3.

    Urban, S. L. et al. Nat. Immunol. https://doi.org/10.1038/s41590-020-0711-8 (2020).

  4. 4.

    Schenkel, J. M. & Masopust, D. Immunity 41, 886–897 (2014).

    Article  CAS  Google Scholar 

  5. 5.

    Smolders, J. et al. Nat. Commun. 9, 4593 (2018).

    Article  CAS  Google Scholar 

  6. 6.

    Wakim, L. M., Woodward-Davis, A. & Bevan, M. J. Proc. Natl Acad. Sci. USA 107, 17872–17879 (2010).

    Article  Google Scholar 

  7. 7.

    Steinbach, K. et al. J. Exp. Med. 213, 1571–1587 (2016).

    Article  CAS  Google Scholar 

  8. 8.

    Mackay, L. K. et al. Proc. Natl Acad. Sci. USA 109, 7037–7042 (2012).

    Article  Google Scholar 

  9. 9.

    Wood, L. M. & Paterson, Y. Front. Cell. Infect. Microbiol. 4, 51 (2014).

    Article  CAS  Google Scholar 

  10. 10.

    Badovinac, V. P., Messingham, K. A. N., Jabbari, A., Haring, J. S. & Harty, J. T. Nat. Med. 11, 748–756 (2005).

    Article  CAS  Google Scholar 

  11. 11.

    Ritzel, R. M. et al. J. Immunol. 196, 3318–3330 (2016).

    Article  CAS  Google Scholar 

  12. 12.

    Logan, S. A. E. & MacMahon, E. Br. Med. J. 336, 36–40 (2008).

    Article  Google Scholar 

  13. 13.

    Gate, D. et al. Nature 577, 399–404 (2020).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Tajie H. Harris.

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Kovacs, M.A., Harris, T.H. Long-‘Trm’ protection of the CNS. Nat Immunol 21, 825–826 (2020). https://doi.org/10.1038/s41590-020-0716-3

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