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One road to the TH17 pathway: how TH1 led to TH17 (and vice versa), and first came last

Casey Weaver recounts how his group’s discovery of the TH17 pathway resolved several conundrums that had arisen in the wake of the original TH1–TH2 hypothesis.

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Fig. 1: The breakthrough.

References

  1. 1.

    Mosmann, T. R., Cherwinski, H., Bond, M. W., Giedlin, M. A. & Coffman, R. L. J. Immunol. 136, 2348–2357 (1986).

    PubMed  CAS  Google Scholar 

  2. 2.

    Harrington, L. E. et al. Nat. Immunol. 6, 1123–1132 (2005).

    Article  CAS  Google Scholar 

  3. 3.

    Hsieh, C.-S., Heimberger, A. B., Gold, J. S., O'Garra, A. & Murphy, K. M. Proc. Natl Acad. Sci. USA 89, 6065–6069 (1992).

    Article  CAS  Google Scholar 

  4. 4.

    Hsieh, C.-S. et al. Science 260, 547–549 (1993).

    Article  CAS  Google Scholar 

  5. 5.

    Janeway, C. A. Jr. Cold Spring Harb. Symp. Quant. Biol. 54, 1–13 (1989).

    Article  CAS  Google Scholar 

  6. 6.

    Powrie, F. et al. Immunity 1, 553–562 (1994).

    Article  CAS  Google Scholar 

  7. 7.

    Oppmann, B. et al. Immunity 13, 715–725 (2000).

    Article  CAS  Google Scholar 

  8. 8.

    Cua, D. J. et al. Nature 421, 744–748 (2003).

    Article  CAS  Google Scholar 

  9. 9.

    Murphy, C. A. et al. J. Exp. Med. 198, 1951–1957 (2003).

    Article  CAS  Google Scholar 

  10. 10.

    Aggarwal, S., Ghilardi, N., Xie, M.-H., de Sauvage, F. J. & Gurney, A. L. J. Biol. Chem. 278, 1910–1914 (2003).

    Article  CAS  Google Scholar 

  11. 11.

    Bettelli, E. & Kuchroo, V. K. J. Exp. Med. 201, 169–171 (2005).

    Article  CAS  Google Scholar 

  12. 12.

    Park, H. et al. Nat. Immunol. 6, 1133–1141 (2005).

    Article  CAS  Google Scholar 

  13. 13.

    Mangan, P. R. et al. Nature 441, 231–234 (2006).

    Article  CAS  Google Scholar 

  14. 14.

    Bettelli, E. et al. Nature 441, 235–238 (2006).

    Article  CAS  Google Scholar 

  15. 15.

    Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M. & Stockinger, B. Immunity 24, 179–189 (2006).

    Article  CAS  Google Scholar 

  16. 16.

    Weaver, C. T., Harrington, L. E., Mangan, P. R., Gavrieli, M. & Murphy, K. M. Immunity 24, 677–688 (2006).

    Article  CAS  Google Scholar 

  17. 17.

    Ivanov, I. I. et al. Cell 126, 1121–1133 (2006).

    Article  CAS  Google Scholar 

  18. 18.

    Lee, Y. K. et al. Immunity 30, 92–107 (2009).

    Article  CAS  Google Scholar 

  19. 19.

    Harbour, S. N., Maynard, C. L., Zindl, C. L., Schoeb, T. R. & Weaver, C. T. Proc. Natl Acad. Sci. USA 112, 7061–7066 (2015).

  20. 20.

    Hirota, K. et al. Nat. Immunol. 12, 255–263 (2011).

    Article  CAS  Google Scholar 

  21. 21.

    Infante-Duarte, C., Horton, H. F., Byrne, M. C. & Kamradt, T. J. Immunol. 165, 6107–6115 (2000).

    Article  CAS  Google Scholar 

  22. 22.

    Ye, P. et al. J. Exp. Med. 194, 519–527 (2001).

    Article  CAS  Google Scholar 

  23. 23.

    Weaver, C. T. & Hatton, R. D. Nat. Rev. Immunol. 9, 883–889 (2009).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The author thanks others in his group as well as colleagues who have contributed much to the discoveries recounted in this article.

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Correspondence to Casey T. Weaver.

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The author declares no competing interest.

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Weaver, C.T. One road to the TH17 pathway: how TH1 led to TH17 (and vice versa), and first came last. Nat Immunol 21, 819–821 (2020). https://doi.org/10.1038/s41590-020-0715-4

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