Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Comment
  • Published:

How should we talk about metabolism?

Nature Immunology volume 21, pages 713–715 (2020)Cite this article

Subjects

Immunologists used to avoid metabolism, but that is no longer possible. Now that we must talk about it, how can we do so in a way that enhances and clarifies our understanding of the role metabolism plays in the immune response?

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Metabolic interconnections.

References

  1. Mills, E. L. et al. Cell 167, 457–470.e13 (2016).

    Article  CAS  Google Scholar 

  2. Tannahill, G. M. et al. Nature 496, 238–242 (2013).

    Article  CAS  Google Scholar 

  3. Infantino, V. et al. Biochem. J. 438, 433–436 (2011).

    Article  CAS  Google Scholar 

  4. Chandel, N. S. Navigating Metabolism (Cold Spring Harbor Laboratory Press, 2015).

  5. Mehta, M. M., Weinberg, S. E. & Chandel, N. S. Nat. Rev. Immunol. 17, 608–620 (2017).

    Article  CAS  Google Scholar 

  6. Ryan, D. G. et al. Nat. Metab. 1, 16–33 (2019).

  7. Murphy, M. P. & O’Neill, L. A. J. Cell 174, 780–784 (2018).

    Article  CAS  Google Scholar 

  8. Martínez-Reyes, I. & Chandel, N. S. Nat. Commun. 11, 102 (2020).

    Article  Google Scholar 

  9. Buck, M. D., Sowell, R. T., Kaech, S. M. & Pearce, E. L. Cell 169, 570–586 (2017).

    Article  CAS  Google Scholar 

  10. Nicholls, D. G. & Ferguson, S. J. Bioenergetics 4 (Academic Press, 2013).

  11. Hindupur, S. K., González, A. & Hall, M. N. Cold Spring Harb. Perspect. Biol. 7, a019141 (2015).

    Article  Google Scholar 

  12. Chen, W. W., Freinkman, E., Wang, T., Birsoy, K. & Sabatini, D. M. Cell 166, 1324–1337.e11 (2016).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

Work in the laboratory of M.P.M. is supported by a grant from the UK Medical Research Council (MC_UU_00015/5) and by a Wellcome Trust Investigator award (110159/Z/15/Z). Work in the laboratory of L.A.O. is supported by the Wellcome Trust.

Author information

Authors and Affiliations

  1. Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK

    Michael P. Murphy

  2. School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland

    Luke A. J. O’Neill

Authors
  1. Michael P. Murphy
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Luke A. J. O’Neill
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Michael P. Murphy or Luke A. J. O’Neill.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Murphy, M.P., O’Neill, L.A.J. How should we talk about metabolism?. Nat Immunol 21, 713–715 (2020). https://doi.org/10.1038/s41590-020-0691-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-020-0691-8

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing