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THYMIC DEVELOPMENT

Forget ‘ME’ not virtual memory T cells

CD8 memory–phenotype differentiation is a T cell antigen receptor–governed process that begins in Eomes+ thymic precursors and is subsequently completed in the periphery. These CD8-MP cells can infiltrate tumors, where they express PD-1.

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Fig. 1: Virtual memory, or CD8-MP T cells, develop by a two-step process.

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Correspondence to Emma Teixeiro.

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Daniels, M.A., Teixeiro, E. Forget ‘ME’ not virtual memory T cells. Nat Immunol 21, 499–500 (2020). https://doi.org/10.1038/s41590-020-0668-7

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