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Forget ‘ME’ not virtual memory T cells

CD8 memory–phenotype differentiation is a T cell antigen receptor–governed process that begins in Eomes+ thymic precursors and is subsequently completed in the periphery. These CD8-MP cells can infiltrate tumors, where they express PD-1.

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Fig. 1: Virtual memory, or CD8-MP T cells, develop by a two-step process.


  1. Miller, C. H. et al. Nat. Immunol. (2020).

  2. Haluszczak, C. et al. J. Exp. Med. 206, 435–448 (2009).

    CAS  Article  Google Scholar 

  3. Akue, A. D., Lee, J.-Y. & Jameson, S. C. J. Immunol. 188, 2516–2523 (2012).

    CAS  Article  Google Scholar 

  4. Lee, J.-Y., Hamilton, S. E., Akue, A. D., Hogquist, K. A. & Jameson, S. C. Proc. Natl Acad. Sci. USA 110, 13498–13503 (2013).

    CAS  Article  Google Scholar 

  5. White, J. T. et al. Nature Commun. 7, 11291 (2016).

    CAS  Article  Google Scholar 

  6. Smith, N. L. et al. Cell 174, 117–130.e14 (2018).

    CAS  Article  Google Scholar 

  7. Renkema, K. R., Li, G., Wu, A., Smithey, M. J. & Nikolich-Zugich, J. J. Immunol. 192, 151–159 (2014).

    CAS  Article  Google Scholar 

  8. Quinn, K. M. et al. Cell Rep. 23, 3512–3524 (2018).

    CAS  Article  Google Scholar 

  9. Drobek, A. et al. EMBO J. 37, e98518 (2018).

    Article  Google Scholar 

  10. Rifa'i, M., Kawamoto, Y., Nakashima, I. & Suzuki, H. J. Exp. Med. 200, 1123–1134 (2004).

    CAS  Article  Google Scholar 

  11. Jameson, S. C., Lee, Y.-J. & Hogquist, K. A. Adv. Immunol. 126, 173–213 (2015).

    CAS  Article  Google Scholar 

  12. Sosinowski, T. et al. J. Immunol. 190, 1936–1947 (2013).

    CAS  Article  Google Scholar 

  13. Miller, B. C. et al. Nat Immunol 20, 326–336 (2019).

    CAS  Article  Google Scholar 

  14. Spranger, S., Dai, D., Horton, B. & Gajewski, T. F. Cancer Cell 31, 711–723.e4 (2017).

    CAS  Article  Google Scholar 

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Correspondence to Emma Teixeiro.

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Daniels, M.A., Teixeiro, E. Forget ‘ME’ not virtual memory T cells. Nat Immunol 21, 499–500 (2020).

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