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A reactive metabolite as an immune suppressant

Myeloid-derived suppressor cells (MDSCs) occupy sites of chronic inflammation and suppress CD8+ T cell function. A new study describes the transfer of the metabolite methylglyoxal (MG) to T cells, which mediates this immunosuppressive mechanism.

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Fig. 1: Methylglyoxal as an immune suppressant in the tumor microenvironment.


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Correspondence to Jason W. Locasale.

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J.W.L. advises Nanocare Technologies, Raphael Pharmaceuticals and Restoration Foodworks.

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Ramesh, V., Locasale, J.W. A reactive metabolite as an immune suppressant. Nat Immunol 21, 497–498 (2020).

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