Myeloid-derived suppressor cells (MDSCs) occupy sites of chronic inflammation and suppress CD8+ T cell function. A new study describes the transfer of the metabolite methylglyoxal (MG) to T cells, which mediates this immunosuppressive mechanism.
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Ramesh, V., Locasale, J.W. A reactive metabolite as an immune suppressant. Nat Immunol 21, 497–498 (2020). https://doi.org/10.1038/s41590-020-0664-y