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Fueling clonal dominance through TRAFficking of NF-κB signaling

Activation of TLR–TRAF6 signaling by chronic inflammation in myelodysplastic syndromes increases the competitive advantage of HSPCs harboring MDS mutations through the upregulation of the ubiquitin-modifying enzyme A20 and a switch from canonical to non-canonical NF-κB signaling.

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Fig. 1: Overexpression of TRAF6 and systemic inflammation support clonal dominance in MDS.


  1. Muto, T. et al. Nat. Immunol. (2020).

    Article  PubMed  Google Scholar 

  2. Barreyro, L., Chlon, T. M. & Starczynowski, D. T. Blood 132, 1553–1560 (2018).

    Article  CAS  Google Scholar 

  3. Will, B. et al. Blood 120, 2076–2086 (2012).

    Article  CAS  Google Scholar 

  4. Chen, J. et al. Nat. Med. 25, 103–110 (2019).

    Article  CAS  Google Scholar 

  5. Will, B. et al. Nat. Med. 21, 1172–1181 (2015).

    Article  CAS  Google Scholar 

  6. Sperling, A. S., Gibson, C. J. & Ebert, B. L. Nat. Rev. Cancer 17, 5–19 (2017).

    Article  CAS  Google Scholar 

  7. Muto, T. et al. J. Exp. Med. 210, 2627–2639 (2013).

    Article  CAS  Google Scholar 

  8. Fang, J. et al. Nat. Immunol. 18, 236–245 (2017).

    Article  CAS  Google Scholar 

  9. Nilsson, L. et al. Blood 100, 259–267 (2002).

    Article  CAS  Google Scholar 

  10. Thanopoulou, E. et al. Blood 103, 4285–4293 (2004).

    Article  CAS  Google Scholar 

  11. Yamaguchi, N., Oyama, M., Kozuka-Hata, H. & Inoue, J. Sci. Rep. 3, 2568 (2013).

    Article  Google Scholar 

  12. Bird, L. Nat. Rev. Immunol. 15, 598 (2015).

    Article  CAS  Google Scholar 

  13. Papa, S. et al. Cell Death Differ. 13, 712–729 (2006).

    Article  CAS  Google Scholar 

  14. Pellagatti, A. et al. Leukemia 24, 756–764 (2010).

    Article  CAS  Google Scholar 

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Correspondence to Ulrich Steidl.

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Ueda, K., Kumari, R. & Steidl, U. Fueling clonal dominance through TRAFficking of NF-κB signaling. Nat Immunol 21, 489–490 (2020).

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