Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Sensing the gut microbiota

Paola Ricciardi-Castagnoli describes how her groups’ focus on mucosal immunity led to the discovery of how dendritic cells sense the gut microbiota to maintain homeostasis.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1.

    Nussenzweig, M. C. & Steinman, R. M. J. Exp. Med. 151, 1196–1212 (1980).

    CAS  Article  Google Scholar 

  2. 2.

    Janeway, C. A. Jr. Cold Spring Harb. Symp. Quant. Biol. 54, 1–13 (1989).

    CAS  Article  Google Scholar 

  3. 3.

    Winzler, C. et al. J. Exp. Med. 185, 317–328 (1997).

    CAS  Article  Google Scholar 

  4. 4.

    Poltorak, A. et al. Science 282, 2085–2088 (1998).

    CAS  Article  Google Scholar 

  5. 5.

    Poltorak, A., Ricciardi-Castagnoli, P., Citterio, S. & Beutler, B. Proc. Natl Acad. Sci. USA 97, 2163–2167 (2000).

    CAS  Article  Google Scholar 

  6. 6.

    Ricciardi-Castagnoli, P. & Granucci, F. Nat. Rev. Immunol. 2, 881–888 (2002).

    CAS  Article  Google Scholar 

  7. 7.

    Granucci, F. et al. Nat. Immunol. 2, 882–888 (2001).

    CAS  Article  Google Scholar 

  8. 8.

    Granucci, F., Zanoni, I., Feau, S. & Ricciardi-Castagnoli, P. EMBO J. 22, 2546–2551 (2003).

    CAS  Article  Google Scholar 

  9. 9.

    Zanoni, I. et al. Nature 460, 264–268 (2009).

    CAS  Article  Google Scholar 

  10. 10.

    Fric, J. et al. Blood 120, 1380–1389 (2012).

    CAS  Article  Google Scholar 

  11. 11.

    Yu, H. B. et al. Nucleic Acids Res. 43, 836–847 (2015).

    CAS  Article  Google Scholar 

  12. 12.

    Rescigno, M. et al. Nat. Immunol. 2, 361–367 (2001).

    CAS  Article  Google Scholar 

  13. 13.

    Farache, J. et al. Immunity. 38, 581–595 (2013).

    CAS  Article  Google Scholar 

  14. 14.

    Fric, J., Zelante, T. & Ricciardi-Castagnoli, P. Front. Immunol. 4, 513 (2014).

    Article  Google Scholar 

  15. 15.

    Zelante, T. et al. Cell Rep. 12, 1789–1801 (2015).

    CAS  Article  Google Scholar 

  16. 16.

    Mencarelli, A. et al. Nat. Commun. 9, 1102 (2018).

    Article  Google Scholar 

  17. 17.

    Wu, H., Peisley, A., Graef, I. A. & Crabtree, G. R. Trends Cell Biol. 17, 251–260 (2007).

    CAS  Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Paola Ricciardi-Castagnoli.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Ricciardi-Castagnoli, P. Sensing the gut microbiota. Nat Immunol 21, 704–705 (2020).

Download citation


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing