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INNATE IMMUNITY

A20 restricts inflammation via ubiquitin binding

The ubiquitin-editing enzyme A20 has a pivotal role in restricting autoimmune and inflammatory responses. New studies suggest that A20 prevents inflammatory diseases using a non-catalytic mechanism involving ubiquitin binding.

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Fig. 1: Inhibition of NF-κB signaling, inflammasome activation and cell death by the ubiquitin-binding zinc fingers of A20.

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Correspondence to Shao-Cong Sun.

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Sun, SC. A20 restricts inflammation via ubiquitin binding. Nat Immunol 21, 362–364 (2020). https://doi.org/10.1038/s41590-020-0632-6

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